benign metastasizing leiomyoma

Their study, supported by conventional karyotypic, fluorescence in situ hybridization, and whole genome SNP array analysis, suggests that both the deep soft tissue leiomyoma and pleuropulmonary BML were derived from the same abnormal clone and are genetically related to uterine leiomyoma.Patton et al., Editor: Stanley J. Robboy, Duke University, UNITED STATES, Received: November 5, 2016; Accepted: March 31, 2017; Published: April 20, 2017. According to the existent literature, lung lesions tend to remain stable [18] with occasional regression after treatment [17]. Anping Cai and Liwen Li drafted the manuscript, Ying Zhang and Yujin Mo facilitated the review draft, and Hong Tan helped to critically review the final version. One BML case [13] was multisystemic (bone, lung, and lymph nodes) in a woman with a renal transplant taking immunosuppressant drugs. Although most commonly seen in the lungs 2, other sites of involvement include lymph nodes, peritoneum, and retroperitoneal structures. Semin Roentgenol.

[1] BML is most common in asymptomatic, perimenopausal women [1], like our patient.

[1] It was first described by Steiner in 1939.

1569121 HeidelbergTel. No significant differences were found in the relationship between the time of the primary surgery and BML diagnosis, with respect to the type of surgery (Table 4A).Furthermore, no significant differences were found in the relationship between the time of the primary surgery and BML diagnosis, with respect to the site of metastasis (Table 4B). They usually have a history of uterine fibroids.

Chest CT, axial image. Endobronchial and pleural sparing are typical. The analysed data, such as the age during the primary surgery, age during BML diagnosis, site and type of metastasis, do not provide us a clear answer. [3] The accumulation of 18-FDG in pulmonary BML varies significantly, with tumours more likely to be non-avid than FDG-avid. The present study reports the case of a 47-year-old female patient who presented with multiple bilateral pulmonary nodules on a chest X-ray during a health checkup nine years after a hysterectomy due to uterine fibroids.

One case [9] reported the simultaneous presence of lung lymphangioleiomyomatosis and BML and the possibility of a common etiopathological ground for both conditions. Estrogen; Leiomyomas; Metastasis; Rare lung disease; Smooth muscle cells.

Data Availability: All relevant data are within the paper and its Supporting Information files. Fasih N, Prasad shanbhogue AK, Macdonald DB et-al.

Managing Patients With Screen-Detected Nodules: The Nodule Clinic. There is a well-circumscribed, rounded, enhancing mass measuring 2.3 cm in the posterior uterine myometrium (2C). The occurrence of metastatic leiomyomas, in all types of surgeries, does not substantiate the claim that any particular type of surgery predisposes their occurrence,particularly because cases have occured wherein BML was diagnosed in women who had not undergone a previous uterine myoma surgery [2–11]. Park, “What are MRI findings of Spine benign metastasizing leiomyoma?

The use of anastrozole permitted further reduction of peripheral estrogen production in order to maximize the possibilities of shrinkage of the masses. Benign metastasizing leiomyoma (BML) is a rare disorder that affects women with a history of uterine leiomyoma, which is found to metastasise within extrauterine sites.The disease develops as a proliferation of multiple nodules composed of smooth muscle cells.The most frequent site of metastasis is the lungs, although other areas may also be affected as well, including some atypical … Following intravenous contrast, the lesions usually enhance homogeneously 3. The Heart as a Site of Metastasis of Benign Metastasizing Leiomyoma: Case Report and Review of the Literature. In this case report, we reviewed a rare case of BML developing in the bone and the lung, in a patient that had not been submitted to a previous hysterectomy. Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules.

Epub 2017 Jun 3. Copyright: © 2017 Barnaś et al. Bitte aktivieren Sie Java-Script in Ihrem Browser, damit Sie alle Vorteile und Funktionen dieser Website nutzen können.


 |  No associated literature or any review publications to date have analysed the compiled date, with respect to the site of metastasis and type of primary surgery.

The condition is characterized by multiple well-differentiated leiomyomas at sites distant from the uterus. Citation: Barnaś E, Książek M, Raś R, Skręt A, Skręt- Magierło J, Dmoch- Gajzlerska E (2017) Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery.

The leiomyomas can metastasize to several organs, the lungs being the most commonly affected. PLOS ONE promises fair, rigorous peer review,

The patient also reported a sensation of pressure in the pelvic region, especially in the lateral decubitus, most likely associated with the mass of the iliac bone. Articles in languages other than English (39), articles containing incomplete data (14), i.e. 2012 Jun;93(6):e149-51.

J Clin Endocrinol Metab 89(7):3183–3188 PubMedCrossRef, Zurück zum Zitat Thukkani N, Ravichandran PS, Das A, Slater MS (2005) Leiomyomatosis metastatic to the tricuspid valve complicated by pelvic hemorrhage.

In EU-Ländern gilt die jeweilige gesetzliche Mehrwertsteuer. Despite this, she needed to resort frequently to taking anti-inflammatory drugs after some physical exertion. Rarely, it has benign extra-uterine growth patterns, including benign metastasizing leiomyoma (BML). As in our case, the lungs are the most frequent site of metastases. Due to the nonspecific appearance of the lesion, the patient underwent an MR of the lumbar spine.

Therefore, we decided that the characteristics of those relations were to be the focus of our investigation to determine their importance in the aetiopathogenesis of the disease.

ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. The majority of case study authors demonstrate the time relation between the patient’s primary surgery and BML onset.To the best of our knowledge, the literature on this subject describes only 10 cases of BML in women who have not undergone prior surgery [2–11]. Benign metastasizing leiomyoma (BML) is a rare disorder that affects women with a history of uterine leiomyoma, which is found to metastasise within extrauterine sites.The disease develops as a proliferation of multiple nodules composed of smooth muscle cells.The most frequent site of metastasis is the lungs, although other areas may also be affected as well, including some atypical locations, e.g. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. One hypothesis is that BML is related to metaplasia of the coelomic epithelium [6]. In order to raise clinicians’ awareness of BML, we present a short review of the literature in combination with an unusual case.

Sawai Y, Shimizu T, Yamanaka Y, Niki M, Nomura S. (2017) Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review. It is not possible to histologically differentiate a BML from a primary uterine leiomyoma. The inclusion criteria were full-text articles in English and articles containing case reports. Chan CY. Cavitation of lesions may occasionally take place and rarely may be accompanied by a pneumothorax. 2.

Bestellen Sie unseren kostenlosen Newsletter Update Kardiologie und bleiben Sie gut informiert – ganz bequem per eMail. The clinical course is typically indolent and spontaneous resolution has been described. There was no referral of previous surgeries or medications. Ann Thorac Surg 79(2):707–709 PubMedCrossRef, Zurück zum Zitat Tietze L, Gunther K, Horbe A et al (2000) Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. A gynaecology opinion was recommended and the patient underwent hysteroscopy and curettage, which revealed multiple benign post-menopausal polyps only, with no evidence of hyperplasia, dysplasia or malignancy.

Copyright © 2016 Elsevier Inc. All rights reserved. BML is a rarely found condition that affects women with a history of uterine leiomyomas. Conventional cytogenetic studies have provided valuable insight, regarding the histopathogenesis of numerous mesenchymal neoplasms.Only scant pulmonary BML has been previously characterised karyotypically.The studies confirmed the presence of karyotypic aberrations in 56% of cases of benign leiomyomas [56–58].Lee et al.

AJR Am J Roentgenol 176(6):1409–1413 PubMedCrossRef, Zurück zum Zitat Steiner PE (1939) Metastasizing fibroleiomyoma of the uterus: Report of a case and review of the literature.

Both the referring doctor and the radiologist should be alert to this diagnosis when a woman with a history of leiomyomas and multiple pulmonary nodules presents at a given context. Therefore, the risk associated with the type of operation cannot be determined.

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